Oncology Articles

Articles

New Advanced Multidisciplinary Prostate Cancer Treatments Provide Individualized Care

Treatments include HDR brachytherapy, radiopharmaceutical treatment, proton therapy and more.

Liquid Biopsy Predicts Early Disease Progression, Potential Survival in Patients with Advanced Breast Cancer

A novel, automated liquid biopsy test in development by researchers at the Johns Hopkins Kimmel Cancer Center can be used to predict early disease progression and potential survival among patients with metastatic breast cancer in as little ...

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Community Cancer Care Linked with Poorer Outcomes for Some HeadNeck Cancers

Care for patients with human papillomavirus (HPV)-related squamous cell cancers of the oropharynx (an area in back of the throat) is shifting toward community cancer centers, but patients treated in this setting may be less likely to survive, ...

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Proton Therapy Case Study—Metastatic Adenocarcinoma of Pancreas with Liver Metastasis

A 63-year-old female was diagnosed with a resectable pancreatic adenocarcinoma.

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Proton Therapy Case Study—Left Frontotemporal Low-Grade Glioma

A 27-year-old male had seizures, dry heaves, described an unpleasant smell and experienced anxiety in November 2020.

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Proton Therapy Case Study—Grade I, ER/PR >90% and HER2 Negative Left Breast Cancer

An otherwise healthy 76-year-old woman was found on screening mammogram to have a new left breast mass. After her workup confirmed a small left breast tumor with no evidence of lymph node involvement, she had a lumpectomy and sentinel ...

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Proton Therapy Case Study—Truncal Soft Tissue Sarcoma

A 74-year-old male was referred to our clinic following resection of a 9 cm myxofibrosarcoma spanning the chest wall and flank.

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Johns Hopkins Adds Surgical Oncology to National Capital Region

Ivey has joined Johns Hopkins as the first surgical oncologist to be based at the Johns Hopkins Kimmel Cancer Center in the National Capital Region. He treats patients at Sibley Memorial Hospital and Suburban Hospital.

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Regular Screening of People at High Risk for Pancreatic Cancer Pays Off

Study finds most patients with pancreatic cancer diagnosed through regular screenings had early-stage disease and long-term survival

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Immunotherapy Plus Chemotherapy Before Surgery Improves Outcomes for Patients with Lung Cancer

Adding the immunotherapy drug nivolumab to chemotherapy before surgery (neoadjuvant) for patients with operable non-small cell lung cancer (NSCLC) — the leading cause of cancer deaths worldwide — reduced the risk of recurrence of the cancer ...

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New Shift in Lung Cancer Treatment with Neoadjuvant Therapy

The approach to treating lung cancer has significantly changed over the last year as a result of new preoperative systemic therapy paradigm shifts. Today, the care pathway is shifting to include medical oncology intervention with neoadjuvant ...

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Johns Hopkins Oncologist Tests Vaccine for Pancreatic Cancer

The first-ever trials for an immunotherapy shot to prevent the lethal form of cancer are underway.

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Drug Combination Gets Advanced Liver Cancer Patients to Surgery

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.

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Targeting Abnormal Cell Metabolism Shows Promise for Treating Aggressive Pediatric Brain Tumors

Two experimental drug approaches that target vulnerabilities in cancer cell metabolism may extend survival and enhance the effectiveness of standard chemotherapies for a highly aggressive type of pediatric brain cancer.

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Advances in Breast-Sparing Surgery for Cancer Patients

Patients with breast cancer have more options than ever before for breast preservation and scar minimization.

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Proton Therapy FAQs for Prostate Cancer

The outlook for patients diagnosed with prostate cancer has improved in recent years. Through advancements in technology, imaging, and treatment delivery, researchers have found ways to better characterize tumors and tailor treatments ...

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Proton Therapy FAQs for CNS Cancer

Proton therapy is a type of advanced radiation treatment. It takes advantage of a remarkable and unique characteristic of high energy particle beams and how they deposit ionizing radiation as they move through the body.

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Proton Therapy Case Study — Breast Cancer

Given the physical characteristics of protons (no exit dose), proton beam therapy may reduce the cardiovascular toxicity of radiation treatment compared to other forms of photon-based external beam radiotherapy by reducing the radiation ...

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Proton Therapy FAQs for Breast Cancer

Through molecular profiling and other technologies, researchers have found ways to better characterize tumors and tailor treatments to the unique tumor signature as well as the overall health of each patient.

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Sibley Memorial Hospital Delivers Individualized Care for Patients with Prostate Cancer

At the Johns Hopkins Kimmel Cancer Center in the Greater Washington, D.C., area, a key step in treating patients with prostate cancer is learning the malignancy’s genetic makeup.

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Proton Therapy Case Study – Prostate Cancer

Current National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology note that proton therapy is an effective and acceptable form of external beam radiation.

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Proton Therapy FAQs for Lung Cancer

Radiation is a powerful tool in the treatment of lung cancer. It is often used in combination with surgery to treat patients with locally advanced disease as well as when surgery is not an option. It is also used to retreat areas of previous disease.

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Proton Therapy Case Study—Lung Cancer

Proton therapy is an alternative to photons in challenging thoracic cancers, particularly in cases where radiotherapy dose to critical organs such as lung or heart must be minimized.

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Proton Therapy Case Study – Skull Base Tumors

A multi-disciplinary team with expertise in skull base neurosurgery, otolaryngology, radiation oncology, pathology and radiology, is needed to achieve the very best outcomes in skull base tumors including chordomas and chondrosarcomas.

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Choosing Proton Therapy at Johns Hopkins

The Johns Hopkins Proton Therapy Center in Washington, D.C., is one of the largest and most advanced centers in the U.S.

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Sibley Memorial Hospital Offers Full Spectrum of Leukemia Care

The Johns Hopkins Kimmel Cancer Center in the greater Washington, D.C., area provides comprehensive leukemia care with access to clinical trials and Johns Hopkins’ hematopoietic stem cell transplant program, including haploidentical tranplant.

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Sibley Memorial Hospital Offers Full Range of Advanced Treatments for Lymphomas

At the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital, clinicians provide proton therapy, immunotherapies and treatments via clinical trials. For complex cases, experts throughout the Johns Hopkins system help determine the best path of care.

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Potential New Treatments for Pancreatic Cancer at Sibley Memorial Hospital

Phase I clinical trials will provide particular patients with novel approaches for the disease, as new Pancreatic Cancer Program is established.

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Molecularly Targeted Therapies for Salivary Gland Cancer

Experts at the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital use highly specialized hormone therapy to target salivary gland tumors based on genetic characteristics.

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New Research: Electrospinning to Deliver Multiple Chemotherapy Drugs to the Brain

A recently published Johns Hopkins study — conducted in collaboration with the University of Cincinnati — shows how electrospun fibers could simultaneously dispense more than one chemotherapy agent to brain tumors.

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Surgery May Add Months or Years of Survival For Adults With Rare And Deadly Brain Cancers

Findings from medical records study could help doctors and patients make more informed treatment decisions

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Johns Hopkins Launches Center for HPV-Related Head and Neck Cancer

New center brings together experts that focus on these unique tumors.

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The Promise of Immunotherapy

Nivolumab (Opdivo) is now FDA approved for treatment of advanced non-small cell lung cancer in patients whose cancers progress on standard therapy, and pembrolizumab (Keytruda) became the first immunotherapy to gain FDA approval as the ...

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A ‘Pesty’ Solution

A new class of cancer-fighting drugs called checkpoint inhibitors is offering hope to patients with several kinds of solid tumors, particularly lung cancer and melanoma. The medications, which work by spurring the body’s immune system ...

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Managing Side Effects of Immunotherapy

Immunotherapy is a promising new therapy that activates the immune system to attack cancer cells. It has a completely different side effect profile than chemotherapy, and that has caught some physicians off guard.

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Autoantibodies Offer Clues to Co-Incidence of Cancer and Scleroderma in Some Patients

The Johns Hopkins Scleroderma Center followed a group of 168 patients with anti-RNA Pol III antibodies for five years, comparing those with and without detectable cancer.

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Same-Day and Next-Day Consultations Offered by Johns Hopkins Surgeons

The expedited appointments allow patients to quickly see a surgical expert at several Johns Hopkins locations in Maryland, including The Johns Hopkins Hospital, the Johns Hopkins Health Care & Surgery Center — Green Spring Station, Johns ...

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Genetic Testing May Hold Promise in Predicting Pancreatic Cancer

Johns Hopkins research suggests that identification of particular genetic mutations could better predict risk and lead to improved survival rates.

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Rapid Response to Immune-Related Adverse Events Improves Patient Care

Published results of a Johns Hopkins pilot study showed 73.5% of physicians in the study said recommendations from an immune-related toxicity (IR-tox) team changed their diagnosis or management of immune-related adverse events.

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Exploring Theranostics for Children

Theranostics is happening in cancer care and nanotechnology, but it is totally unexplored in the pediatric setting. We have a wide open field in which it can be applied in cancer treatments for children, and in vascular and cardiac care.

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Favorable Five-Year Survival Reported For Patients With Advanced Cancer Treated With The Immunotherapy Drug Nivolumab

Favorable five-year survival rates from the first multidose clinical trial of the immunotherapy drug nivolumab (anti-PD-1) reported.

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5-Hour Test Accurately Detects Breast Cancer

In a pilot study, Johns Hopkins Kimmel Cancer Center researchers found that a new five-hour lab test accurately detected whether breast tumors are cancerous or benign.

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New Algorithm Aims for Early Detection of Pancreatic Cancer

It must learn to find the “known unknown” — for instance, patterns in texture in scans that may be invisible to the human eye but indicate an early abnormality in the pancreas.

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Turning Silenced Cancer Genes Back Into Fighters

Targeting protein known as UHRF1 may shrink tumors by restoring aberrant gene regulation in cancer cells.

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Out of Many Ovarian Precancerous Lesions, One Becomes Cancer

Some deadly ovarian cancers arise from lesions genetically unrelated to each other

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Muscle Gene Mutations Implicated in Human Nasal/Sinus Cancer

Johns Hopkins researchers report they unexpectedly found the same genetic change–one in a gene involved in muscle formation–in five of the tumors.

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Research Points to Genetic Underpinnings of Olfactory Neuroblastoma

The study, led by Johns Hopkins neurosurgeon-scientists, sheds light on the mechanisms involved in cancer and could lead to new treatments for olfactory neuroblastoma. Image shows cellular image of neuroblastoma.

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Precision Medicine for Patients with Neurofibromatosis

Neurofibromatosis Precision Medicine Center of Excellence works to mine untapped volumes of clinical data and use it for research that can benefit patients with neurofibromatosis.

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A Continuum of Convenient and Comprehensive Lung Cancer Care

Radiation oncologist Russell Hales, thoracic surgeon Richard Battafarano and medical oncologist Julie Brahmer are among the caregivers offering comprehensive lung cancer treatment across a continuum of care in Maryland and the Washington, D.C., region.

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Johns Hopkins Delves Deeply into Neoadjuvant Therapies for Lung Cancer

Program provides best possible care for patients while offering opportunities to participate in cutting-edge clinical trials, including those involving immunotherapies.

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Johns Hopkins Offers Rare, One-Day Lung Cancer Clinic

Data show that approach lengthens lives and saves health care dollars.

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Matching Patient with Treatment

New Johns Hopkins analytics platform increases physicians’ ability to personalize medicine.

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Johns Hopkins Developing New Test for Esophageal Cancer

A Johns Hopkins gastroenterologist and a team of researchers use specific genetic biomarkers to detect dangerous changes in the cells that line the inside of the esophagus. 3D image shows concept model of esophageal cancer.

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Glowing Tumors Show Scientists Where Cancer Drugs Are Working

The glow could someday help us use cancer drugs more efficiently.

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Rare Gastrointestinal Cancers Aren’t So Rare to Johns Hopkins Team

Certain gastrointestinal tumors — especially those found in the stomach and peritoneal cavity — are rare and complex, requiring a highly skilled team of specialists who collaborate to individualize multimodal treatment plans.

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Blood Diseases Cured With Bone Marrow Transplant

Johns Hopkins researchers have found a new treatment method could offer a significantly higher chance of a cure for patients with severe and deadly inherited blood disorders.