PD20-07: Oncologic Outcomes in Patients with Variant Histologies of Upper Tract Urothelial Cancer: Results from an International Multicenter Cohort
Maximilian Pallauf, MD
Authors: Maximilian Pallauf, Sean A. Fletcher, Michael Rezaee, Morgan Rouprêt, Stephen A. Boorjian, Aaron M. Potretzke, Hooman Djaladat, Alireza Ghoreifi, Francesco Soria, Andrea Mari, Riccardo Campi, Zine-Eddine Khene, Eiji Kikuchi, Michael Rink, Kazutoshi Fujita, David D'Andrea, Joost L. Boormans, Guillaume Ploussard, Alberto Breda, Firas Abdollah, Jay D. Raman, Shahrokh F. Shariat, Benjamin Pradere, and Nirmish Singla
Full Abstract: https://www.auajournals.org/doi/10.1097/01.JU.0001009556.54476.eb.07
I will be presenting at a UA a project titled Oncological Outcomes in patients with current histologist of upper tract cancer results from an International Multi center cohort. The rationale behind this study was to learn more about the vent histologist in a tract cancer which have been poorly described in the literature. So far required an international Multi center cohort of upper tract cancer patients who were nonmetastatic and were treated with radical nephrectomy. Based on the pathology report, we stratified those patients into pure UIC carcinoma and varum histology. The variant histology group was further divided based on the subtype. We formed two distinct groups. The first was the squamous gland plastic subtype group which was the subtype most frequently identified. The second group comprised all other variant histology subtypes. We compared clinical pathologic characteristics and oncological outcomes between the groups. The letter was performed on a pa uh match by pathologic stage. So we compared organ confined and non organ confined disease separately. We included 3435 patients and identified 201 with variant histology, which is roughly 6% patients with variant histology exhibited more aggressive disease and received perative system therapy more frequently compared to those with pure carcinoma. The gram gland a troop plastic septic cohort had similar oncologic outcomes is pure ether carcinoma. However, other vent histologist demonstrated worse stage match recurrence free and overall survival. The project showed that despite the increased use of systemic therapy, certain variant histology subtypes had worse oncological outcomes than pure ure carcinoma in arac ure cancer. Further studies burn it to elucidate the biology of different barn histology subtypes to optimize treatment approaches.
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