Experts from Johns Hopkins Children’s Center participated in various sessions and presentations during the 2023 Pediatric Academic Societies Meeting. In this video, pediatric cardiologist Allen Everett and neuroscientist Lauren Jantzie discuss their research on cyclohexanone (CXO) and brain connectivity functions. CXO is an organic solvent that is ubiquitous in the ICU environment and common in IV bags and stopcocks to IV tubing. Neonates who had cardiac surgery are exposed to this solvent in the PICU. In this study, the researchers explore the neurodevelopment of neonates who are exposed to CXO.
Good morning. I'm Alan Ever. Um a pediatric cardiologist at Johns Hopkins and professor of pediatrics. And I'd like to talk to you about our abstract perinatal exposure to Cyclohexane induces profound behavioral deficits in adults including hyperactivity and disinhibition. Uh We've known for a long time that uh neonates who have cardiac surgery uh have significant neurodevelopmental uh deficits that last life long. These include motor learning uh and hyperactivity. Uh But we've never really had a, a clear understanding about what causes this. But we've identified in our research is the exposure of chi Children during cardiac surgery to organic. So, one called Cyclo hexen uh in the cardio Pulmonary bypass circuit. And we found in an association study that exposure to this material produces uh uh worse or developmental outcomes. What the abstract identifies as a, is a real causal link using an animal model that exposure cyclo hexen really a uh significantly affects uh brain function uh in animals. Thank you. Hi. My name is Doctor Lauren Jay and I'm an associate professor at pediatrics at the Johns Hopkins Children's Center. I'm also a pediatric neuroscientist. I'm really excited today to talk to you about uh some science that we just presented at the annual meeting of the pediatric academic societies. Cyclohexane is an organic solvent sealer for polyvinyl chloride I V bags and stock cos it is ubiquitous in an IC U environment. Given the number of plastics and infusion tubing that is used. High levels of cyclohexane breakdown products have been shown by my colleagues to be in the urine of patients in the N U. And similarly, um there is a large serum increase in cyclohexane in Children that have undergone cardiac surgery. And these elevated levels of psycho hexen in the bodies of Children undergoing cardiac surgery are independently associated with poor neurodevelopmental outcomes. And so, in my lab, together with my colleagues, we wanted to test that exposure to clinically relevant levels of cyclohexane. In the lab is causal for functional neurodevelopmental deficits including hyperactivity and to elucidate. The mechanism of whether this could be similar to those kinds of deficits as observed in Children after neonatal cardiac surgery. So, using a preclinical model, we exposed young rats to cycle hexen. And we found that clinically relevant exposure levels of psycho he caused profound hyperactivity, hypermobility and disinhibition. And this was accompanied by a very unique gate deficit and uh problems in stances, posture, walking and gate kinematics. And this was very similar to what has been observed in Children exposed to psycho hexen levels in cardiac surgery. And so, in summary, what we found is that cycle hex exposure in an animal model, using human equivalent levels of cyclohexane produced hyperactivity and motor abnormalities that persisted into adulthood. And additional studies from us are needed to establish the mechanisms of this action and to discover new avenues for neuro repair for these Children. And also of course, novel avenues to reduce medical cycle, hexen exposures. Thank you.
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