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Understanding the Role of Cancer and Myositis

Johns Hopkins rheumatologist Lisa Christopher-Stine shares what is known about how the disease processes of cancer and myositis intertwine.

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Anti-vinculin Antibodies in Systemic Sclerosis: Associations with Slow Gastric Transit and Extra-Intestinal Clinical Phenotype

Gastrointestinal symptoms are common in people with systemic sclerosis. Rheumatologist Zsuzsanna McMahan shares her finding of a relationship between an antibody that may contribute to issues in the gastrointestinal tract in systemic sclerosis patients.

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Improved Overall Survival in Patients with Lung Cancer and Autoimmune Rheumatic Diseases

Multidisciplinary collaboration is crucial for rheumatologist Laura Cappelli. Her recent study, conducted with Johns Hopkins oncologists, showed that patients with both an rheumatic disease and lung cancer who were diagnosed earlier had ...

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Skeletal Myopathy in Systemic Sclerosis Associated with Higher Disease Burden and Mortality

Occasionally, patients with scleroderma also have or develop skeletal myopathies. Rheumatologist Julie Paik explains her recent study findings that these comorbidities lead to increase disease burdens and morbidity.

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Chimeric autoantigen-T cell receptor (CATCR)-T cell therapies to selectively target autoreactive B cells

Immunotherapies are often effective when treating autoimmune disease and cancer but often lead to impaired immune function.

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Change in Urinary Biomarkers at Three Months Predicts 1-year Treatment Response of Lupus Nephritis Better than Proteinuria

Rheumatologist Andrea Fava has identified accurate, noninvasive biomarkers found in urine that can be used to better diagnose and guide treatment for lupus nephritis.

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Association Between Anti-Sjogren Syndrome/Scleroderma Autoantigen 1 (SSCA1) Antibodies and Cancer in Systemic Sclerosis

Rheumatology fellow Rachel Wallwork discusses her latest research results on how an antibody in systemic sclerosis patients with cancer may be a key biomarker to predict possible cancer development.

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Tailoring Care for Older Patients — Understanding Health Status, Life Expectancy and Preferences

Johns Hopkins geriatrician Nancy Schoenborn discusses her research regarding cancer screening decisions for older adults and the importance of considering each patient’s health status, life expectancy and preferences when deciding if and ...

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Making Health Care Safer for Older Adults

Geriatrician Alicia Arbaje discusses research on the role of culture in transitions of care and how health care systems can be made safer by understanding the experience of older adults.

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Getting Under the Skin: The Association Between Social Isolation and Inflammatory Markers

Geriatrician Thomas Cudjoe discusses the relationship between social isolation and inflammatory biomarkers. Findings from a large nationally represented study indicate that social isolation has biological influences and could lead to poor health outcomes.

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Research Discoveries on Diabetic Foot Wound Care at Johns Hopkins

Vascular surgeon Christopher Abularrage, M.D. discusses recent research pertaining to diabetic foot wounds and best practices.

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Differences in Proton and Photon Therapy, Johns Hopkins Medicine

Curtiland Deville, MD, compares photon and proton treatment options in lung and sarcoma cases.

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#TomorrowsDiscoveries: Rethinking the Spread of Metastatic Cancer

Finding ways to make cancer cells unable to spread, and ways to make other organs less fertile for cancer to take root.

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Proton Therapy Expertise

Dr. Curtiland Deville discusses his experience with proton therapy and the technology, research and treatment that will be conducted at The Johns Hopkins Proton Therapy Center

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#TomorrowsDiscoveries: Improving Radiation Treatments for Children

Dr. Stephanie Terezakis and her research team are looking for ways to deliver radiation more precisely to tumors and minimize radiation to healthy tissues.

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#TomorrowsDiscoveries: Heart Attack in a Dish

Dr. Brian O’Rourke and his laboratory study how mitochondria, the cellular powerhouses of the heart, contribute to heart attacks and heart failure.

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#TomorrowsDiscoveries: Atypical Parkinsonian (Parkinson-Plus) Disorders

Dr. Alexander Pantelyat and his team collect blood and spinal fluid for genetic and proteomic analyses by using novel brain imaging techniques to distinguish between types of Parkinson’s-plus syndromes.

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#TomorrowsDiscoveries: Therapy for Aortic Aneurysms - Dr. Hal Dietz

Johns Hopkins researchers have identified the genes responsible for aortic ballooning and the sequence of events leading to aortic aneurysms.

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#TomorrowsDiscoveries: Preserving Memory | Mollie K. Meffert, M.D., Ph.D.

Dr. Mollie Meffert and her team investigate how genes and electrical flow interact to strengthen connections between neurons.

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#TomorrowsDiscoveries: Strengthening Lungs before Transplants | Errol Bush, M.D.

Dr. Errol Bush and his team are developing a “lung-in-box” program to strengthen donor lungs before transplantation. Their goal is to ensure high quality of life for recipients.

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#TomorrowsDiscoveries: Using Technology to find Organ Donors | Andrew Cameron, M.D., Ph.D.

#TomorrowsDiscoveries: Andrew Cameron, a liver transplant surgeon, recognizes that many people wait on the transplant list. He and his team worked with Facebook to allow people to show their friends they are registered organ donors.

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#TomorrowsDiscoveries: Rebuilding Tissues and Organs | Jennifer Elisseeff, Ph.D.

Dr. Elisseeff and her team are designing scaffolds to help our bodies heal themselves after injury. Discover more at: http://www.hopkinsmedicine.org/resear...

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#TomorrowsDiscoveries: Healing by Regeneration | Luis Garza, M.D., Ph.D.

#TomorrowsDiscoveries: Dermatologist Luis Garza is working to reactivate the codes that allowed our cells to build our organs. Harnessing this code as adults could change typical healing from scarring to regeneration.

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#TomorrowsDiscoveries: Stopping the Spread of Breast Cancer Cells | Andrew Ewald, Ph.D.

Cell biologist Andrew Ewald and his team have discovered what allows breast cancer cells to leave the main tumor and build new tumors in the lungs, bones and brains. Now, their goal is to identify patients whose breast cancer is likely ...

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#TomorrowsDiscoveries: Exploiting the Weakness of Mosquitoes | Christopher Potter, Ph.D.

Neuroscientist Christopher Potter and his team understand that mosquitoes pass on a disease through a simple bite. They are working to understand how an insect’s brain interprets and responds to odors.

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#TomorrowsDiscoveries: Devising Treatments to Block Rogue Genes | Dr. Philip Cole

#TomorrowsDiscoveries: Dr. Cole and his team are developing chemical techniques to block the action of disease-causing genes. They plan to use these techniques to develop new therapies.

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#TomorrowsDiscoveries: How to Eliminate Eye Drops | Dr. Peter McDonnell

Many patients worry about not being able to get their eye drops into their eyes. They may miss their eyes with squeeze bottles, or in some cases scratch their eyes.

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#TomorrowsDiscoveries: A Missile for Cancer | Dr. Theodore DeWeese

#TomorrowsDiscoveries: Dr. DeWeese and his team are testing a way to target a protein found on the surface of cancer cells, but not non-cancer cells. Their goal is to destroy cancer while protecting normal tissue.

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#TomorrowsDiscoveries: Why Eating Too Much Sugar Can Be Harmful | Dr. Gerald Hart

#TomorrowsDiscoveries: How does eating too much sugar lead to health problems? Dr. Hart explains the connection between dietary sugar and a unique sugar in our bodies that alters proteins’ function in response to nutrients and glucose.

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#TomorrowsDiscoveries: Connecting Heart Failure and Arrhythmias | Dr. Mark Anderson

#TomorrowsDiscoveries: Heart failure means that the heart is unable to pump enough blood, while heart arrhythmias occur when the heart’s electrical system is disorganized. Dr. Anderson and his team want to understand why heart failure ...

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#TomorrowsDiscoveries: Toward a Treatment for Barth Syndrome | Dr. Hilary Vernon

#TomorrowsDiscoveries: Mitochondria are the powerhouses of the cell, producing the energy we need to live. So it’s no surprise that problems with mitochondria have severe effects on the body. One of these is Barth Syndrome, a failure of ...

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#TomorrowsDiscoveries: Innovative Strategies for Treating Brain Tumors | Dr. Henry Brem

#TomorrowsDiscoveries: Normal brain tissue must be protected while doctors destroy a brain tumor. Researchers at Johns Hopkins are creating new, targeted treatments for brain tumor patients.

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#TomorrowsDiscoveries: Giving Immune Response a Nano-Boost | Dr. Jonathan Schneck

Can a custom-built white blood cell avoid suppression by cancer and boost our immune system? Dr. Jonathan Schneck has developed “artificial antigen-presenting cells” and is working to put them to use in the clinic.

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#TomorrowsDiscoveries: Intellectual Disability Treatments | Dr. Hans Bjornsson

Dr. Hans Bjornsson studies proteins bound to our DNA to find causes and potential treatments for a disease called Kabuki syndrome. His work may lead to one of the first treatments for an inborn intellectual disability.

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#TomorrowsDiscoveries: Energy for a Longer Life | Dr. Dan Arking

Dr. Dan Arking explores the links between the number of energy-producing mitochondria in human blood cells, genetics and frailty.

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#TomorrowsDiscoveries: Monitoring Transplanted Stem Cell Fate | Dr. Assaf Gilad

Dr. Assaf Gilad is developing new technologies to “tag” stem cells and monitor cell fate with MRI, improving patient safety and treatment outcomes, especially for those with brain cancer and heart disease.

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#TomorrowsDiscoveries: Chemotherapy-Resistant Breast Cancer Stem Cells | Dr. Gregg Semenza

Dr. Gregg Semenza’s team has identified a way to overcome the resistance of cancer stem cells to chemotherapy, completely eradicating breast tumors in mice.

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#TomorrowsDiscoveries: Using Stem Cells to Treat Blood Disorders | Dr. Elias Zambidis

Dr. Elias Zambidis cares for children suffering from leukemia and other blood disorders.

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#TomorrowsDiscoveries: Treating Prostate Cancer – Urologic Oncologist Kenneth Pienta

Urologic oncologist Kenneth Pienta and his team are working to identify what keeps disseminated tumor cells asleep or reactivates them so that they can better treat prostate cancer.

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New Frontiers in Geriatric Medicine

Johns Hopkins Medicine is conducting important research on the biology of health aging, which will ultimately benefit millions of Americans over the age of 65.